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Susceptibility also increases in the presence of genital inflammation, which increases the number of cells in genital secretions that can be targeted by HIV. J Gen Intern Med. Sexually transmitted infections STIs: First, we used a 4-point scale Never to Very Often. The comorbidity of depression and substance use disorders. These findings document the need for intervention approaches that do not simply make available condoms and HIV education for heterosexual Black men but also alter structural risk factors that maintain high rates of HIV and STI in their neighborhoods and their lives.